TABLE 2.

Prenatal diagnosis of congenital HCMV infection: diagnostic value of four different assays for HCMV detection in 65 AF samples^a

Assay	Result	No. of samples in which HCMV congenital infection was:		Sensitivity (%)	Specificity (%)	NPV (%)	PPV (%)
		Present (n = 31)	Absent (n = 34)
Virus isolation	Pos.	29	0	93.5	100	94.4	100
	Neg.	2	34
PCR	Pos.	29	0	93.5	100	94.4	100
	Neg.	2	34
IE mRNA	Pos.	29	1	93.5	98.5	94.4	96.8
	Neg.	2	33
pp67 mRNA	Pos.	29	0	93.5	100	94.4	100
	Neg.	2	34

^aAbbreviations: NPV, negative predictive value; PPV, positive predictive value.