TABLE 6.
Detection of HPV16 E7-reactive CD8+ T cells in patients with cervical cancera
Donor no. | PBL
|
TIL
|
Lymph node T cells
|
HPV16 status of tumor | ||||||
---|---|---|---|---|---|---|---|---|---|---|
CD3+ CD8+ (%) | HPV (%) | CMV (%) | CD3+ CD8+ (%) | HPV (%) | CMV (%) | CD3+ CD8+ (%) | HPV (%) | CMV (%) | ||
1 | 3.45 | 0.02 | ND | 14.7 | 0.00 | ND | 6.45 | 0.00 | ND | + |
2 | 14.2 | 0.02 | 0.06 | 52.4 | 0.01 | 0.02 | ND | ND | ND | + |
3 | ND | ND | ND | 13.7 | 0.02 | 0.01 | ND | ND | ND | + |
4 | 16.7 | 0.04 | 1.00 | ND | ND | ND | ND | ND | ND | + |
5 | 6.74 | 0.02 | ND | ND | ND | ND | ND | ND | ND | + |
6 | 23.2 | 0.00 | 0.10 | 46.4 | 0.00 | 0.03 | 4.28 | 0.00 | 0.01 | + |
7 | 15.1 | 0.06 | 0.72 | ND | ND | ND | ND | ND | ND | + |
8 | 17.6 | 0.02 | 0.03 | 14.8 | 0.02 | ND | ND | ND | ND | + |
9 | ND | ND | ND | 8.57 | 0.00 | 0.02 | ND | ND | ND | + |
10 | ND | ND | ND | 14.4 | 0.00 | ND | ND | ND | ND | − |
11 | 18.6 | 0.00 | 0.00 | ND | ND | ND | ND | ND | ND | + |
12 | 22.2 | 0.03 | ND | ND | ND | ND | ND | ND | ND | + |
13 | 9.57 | 0.47 | 0.30 | 26.6 | 0.02 | 0.01 | 24.7 | 0.04 | 0.01 | + |
14 | 38.1 | 0.18 | 0.69 | ND | ND | ND | ND | ND | ND | + |
15 | 15.1 | 0.01 | 0.26 | 20.0 | 0.04 | 0.37 | ND | ND | ND | + |
16 | 14.2 | 0.00 | 0.00 | 15.7 | 0.03 | ND | ND | ND | ND | + |
17 | 17.1 | 0.00 | 0.02 | 9.02 | 0.01 | 0.00 | 8.91 | 0.00 | 0.01 | − |
18 | 15 | 1.6 | 1.7 | 43.5 | 0.08 | 0.00 | 19.81 | 0.03 | 0.4 | + |
See footnotes to Table 5 for details.