TABLE 1.
In vitro and in vivo characteristics of HTLV-1-infected cell lines
| Cell line | Origina | In vitro characteristics
|
No. of cells inoculated/mouse (107)c | In vivo characteristics
|
||||
|---|---|---|---|---|---|---|---|---|
| Proliferation pattern | Taxb | Inoculation routed | No. of mice with visible tumor/no. of mice inoculatede | Day of sacrifice | Average size of tumor (mm)f | |||
| ED-40515(−) | L | Dispersed | − | 1 | s.c. | 37/37 | 15 | 25 × 20 × 12 |
| 7.5 | i.m. | 1/1 | 15 | 23 × 18 × 12 | ||||
| SLB-1 | IT | Clustered | + | 1 | s.c. | 15/15 | 15 | 19 × 10 × 16 |
| 7.5 | i.m. | 1/1 | 15 | 20 × 10 × 15 | ||||
| MT-1 | L | Dispersed | − | 1 | s.c. | 7/7 | 22 | 22 × 15 × 10 |
| 7.5 | i.m. | 1/1 | 20 | 21 × 14 × 10 | ||||
| TL-oml | L | Dispersed | − | 1 | s.c. | 7/7 | 22 | 23 × 15 × 10 |
| 7.5 | i.m. | 1/1 | 20 | 18 × 15 × 10 | ||||
| Hut-102 | IT | Clustered | + | 1 | s.c. | 4/4 | 22 | 21 × 13 × 16 |
| 7.5 | i.m. | 1/1 | 20 | 10 × 10 × 7 | ||||
| MT-2 | IT | Clustered | + | 7.5 | s.c. | 1/1 | 20 | 10 × 9 × 8 |
| 7.5 | i.m. | 1/1 | 20 | 9 × 10 × 7 | ||||
| MT-4 | IT | Clustered | + | 7.5 | s.c. | 1/1 | 20 | 5 × 5 × 4 |
| 7.5 | i.m. | 1/1 | 20 | 5 × 4 × 3 | ||||
| M8116 | IT | Clustered | + | 7.5 | s.c. | 0/1 | 20 | Sesame |
| 7.5 | i.m. | 0/1 | 20 | Sesame | ||||
| TY8-3/MT-2 | IT | Clustered | + | 7.5 | s.c. | 0/1 | 20 | Sesame |
| 7.5 | i.m. | 0/1 | 20 | Sesame | ||||
a
L, leukemic; IT, in vitro transformed.
b
−, negative; +, positive.
c
Mice were injected with 1 × 107 to 7.5 × 107 cells per mouse.
d
s.c., subcutaneous; i.m., intramuscular.
e
Number of animals in which visible tumor developed.
f
Average tumor size of individual mouse was measured as described in Materials and Methods and is given here as length × width × height.