TABLE 2.
Infiltration of leukemic cells into different organs of SCID micea
| Cell line | Infiltration of leukemic cells into:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Tumor | Peripheral blood | Bone marrow | Liver | Spleen | Lung | Brain | Kidney | Heart | |
| ED-40515(−) | +++ | ++ | ± | + | + | + | ± | + | − |
| SLB-1 | +++ | +++ | ++ | +++ | ++ | +++ | + | + | + |
| MT-1 | +++ | ++ | − | + | + | + | + | − | − |
| TL-oml | +++ | ++ | − | +++ | + | ± | − | − | − |
| Hut-102 | +++ | ++ | +++ | +++ | +++ | + | ± | − | − |
| MT-2 | ++ | + | ± | ± | + | ± | − | + | − |
| MT-4 | ++ | + | ± | − | + | − | − | − | − |
| M8116 | + | ± | − | − | − | − | − | − | − |
| TY8-3/MT-2 | + | − | − | − | − | − | − | − | − |
a
Mice were injected with 1 × 107 to 7.5 × 107 cells per mouse. Tumor tissue and organ samples were examined by histological analysis. Symbols: +, slight infiltration; ++, marked infiltration; +++, massive infiltration; ±, slight or no infiltration, depending on each mouse; −, no infiltration.