TABLE 2.
Characterization of RSV variants resistant to VP-14637
| Virus | VP-14637 EC50 (nM)a | Resistance to VP-14637b (fold) | F genotype |
|---|---|---|---|
| RSV A2 | 0.90 | 1.0 | Wild type |
| Untreated Ac | 0.85 | 0.94 | Wild type |
| Untreated Bc | 0.72 | 0.80 | Wild type |
| VP-14637 A | >1,000 | >1,000 | F488Y |
| VP-14637 B | >1,000 | >1,000 | T400A |
a
EC50 values were determined in the standard antiviral assay described in Materials and Methods.
b
Resistance was calculated by dividing the EC50 of VP-14637 for the selected viral isolate by the EC50 for wild-type RSV A2.
c
Viruses passaged in the absence of compound. A and B represent two independent selections.