Table 1.

Summary of epigenotype/genotype interactions in colorectal tumors

Group	Epigenotype	MINT methylation*	p16 methylation	K-RAS mutations	p53 mutations	TGFβRII mutations	MSI
Cancer, first series, n = 41	CIMP+, n = 21, 51%;	4.7	62%†	62%§	24%‡	33%	24%
	CIMP−, n = 20, 49%	0.3	0%	25%	68%	21%	21%
Cancer, second series, n = 47	CIMP+, n = 20, 42%;	4.0	40%‡	75%‡	25%§	ND	ND
	CIMP−, n = 27, 58%	0.3	0%	33%	63%	ND	ND
Adenomas, n = 45	CIMP+, n = 22;	4.5	55%†	68%‡	5%	ND	ND
	CIMP−, n = 23	0.4	0%	13%	22%	ND	ND
All cases, n = 133	CIMP+, n = 63;	4.4	53%†	68%†	18%†	ND	ND
	CIMP−, n = 70	0.3	0%	24%	51%	ND	ND

ND, not determined. 

^*Average of six. 

^†P < 0.0001. 

^‡P < 0.01. 

^§P < 0.05 (compared to CIMP⁻ cases).