FIG. 3.

Virulence of bunyaviruses in 129 wt, PKR(−/−), and RNase L(−/−) mice. Groups of six 5-week-old specific-pathogen-free female mice (kindly obtained from Jovan Pavlovic, University of Zurich, Switzerland) were inoculated intracerebrally with 1,000 PFU of wt BUN (A) or BUNdelNSs (B) viruses. The animals were monitored twice daily over an 8-day period. Mice that were moribund or severely paralyzed were killed and scored dead on the day these symptoms were observed.