TABLE 1.
Recombinant antigens used in this study
| Rv designationa | Mb designationb | Synonym(s) | Size (aa) | Function/characteristicc | Rank ind:
|
Reference(s) | |
|---|---|---|---|---|---|---|---|
| Humans | Cattle | ||||||
| Rv0125 | Mb0130 | Mtb32a | 355 | Probable serine protease (C>L) | 8 | 6 | 38 |
| Rv0287 | Mb0295 | Mtb9.8, EsxG | 97 | ESAT-6-like protein (ND) | 1 | 1 | 1 |
| Rv0915c | Mb0939c | PPE14, Mtb41 | 423 | PPE family protein (ND) | 6 | 5 | 39 |
| Rv1174c | Mb1207c | Mtb8.4 | 110 | Secreted protein (C) | 7 | 3 | 11 |
| Rv1196 | Mb1228 | PPE18, Mtb39a | 391 | PPE family protein (L) | 3 | 2 | 15 |
| Rv1793 | Mb1821 | Mtb9.9A, EsxN | 94 | ESAT-6-like protein (L>C) | 5 | 7 | 2 |
| Rv1886c | Mb1918c | Ag85B, MPT59 | 325 | Secreted, mycolyl transferase (C>L) | 4 | 4 | 1, 3 |
| Rv2945c | Mb2970c | Lppx | 233 | Lipoprotein (ND) | NA | NA | 6 |
| Rv3616c | Mb3646c | 292 | A+G-rich protein, unknown function (ND) | 2 | 1 | 1, 19 | |
| Rv3874 | Mb3904 | CFP-10, EsxB | 100 | ESAT-6-like protein (C>L) | NA | NA | 3, 41 |
| Rv3875 | Mb3905 | ESAT-6, EsxA | 95 | ESAT-6-like protein (C>L) | NA | NA | 5 |
a
Designations of M. tuberculosis H37Rv proteins are according to those described by Cole et al. (10).
b
Corresponding designations of M. bovis AF2122/97 proteins are according to those described by Garnier et al. (21).
c
Protein function or functional characteristic, with subcellular location in parentheses: L, found in bacterial lysates; C, in culture filtrates; ND, not determined.
d
Immunogenicity ranking according to IFN-γ responder frequencies as described for M. tuberculosis-infected humans (1) or M. bovis-infected cattle (this study). 1= most frequently recognized. NA, not applicable.