FIG. 1.

IgA ASC response to HoM, CR, and HeT CFs in patients infected with enterotoxigenic Escherichia coli. The IgA antibody-secreting cell responses in patients with CFA/I (a [n = 25])-, CS14 (b [n = 11])-, CS5 (c [n = 15])-, and CS7 (d [n = 8])-expressing ETEC to HoM, CR, and HeT CF antigens are shown. The responses to CFA/I (•), CS4 (▴), CS5 (▾), CS7 ( ), and CS14 (▪) after onset of diarrhea (Acute) (day 2) and at early convalescence stage (Conv.) (day 7) are shown. Asterisks indicate statistically significant differences (*, P < 0.05 to 0.01; **, P < 0.01 to 0.001) between the acute and convalescent phases. The symbols indicate geometric means, and vertical lines indicate SEM. The responses in the 20 healthy subjects are also shown in panel a (GM of responses are depicted as open symbols for CFA/I [○], CS4 [▵], CS5 [▿], CS7 [○], and CS14 [□]). The cutoff value for a response to CF antigens is also shown in panel a (≥5 ASCs/10⁶ PBMCs [—]) for healthy control (HC).