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Vaccination of mice with rV10 provides protection against bubonic plague. BALB/c mice were immunized intramuscularly with adjuvant alone (Alhydrogel), rLcrV, or rV10 in a two-dose regimen (50 μg of purified, endotoxin-free antigen injected on day 0 and 21). On day 43 postimmunization, mice were challenge with 100,000 MLD of Y. pestis CO92 by subcutaneous injection, and survival was monitored.
