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. 2003 May;77(9):5209–5217. doi: 10.1128/JVI.77.9.5209-5217.2003

FIG. 2.

FIG. 2.

IgG anti-LPS responses elicited in serum in cotton rats immunized i.n. with various doses of vaccine strain serovar Typhi (upper panel) or S. flexneri 2a (lower panel). Cotton rats were inoculated i.n. with 7.4 × 107 to 7.4 × 109 CFU of CVD 908-htrA or 3.0 × 107 to 3.0 × 109 CFU of CVD 1208 suspended in a 20-μl volume. A control group received 20 μl of PBS i.n. IgG anti-LPS titers were measured by ELISA in serum samples collected 21 days after immunization. Bars indicate the GM titers ± the SE from four animals. ✽, Significant increases (P < 0.05) in antibody titers compared to preimmunization levels and control group. EU, ELISA unit(s).