FIG. 2.

Alignment of E4 ORF3 proteins and point mutations. The sequences of E4 ORF3 proteins from multiple Ad serotypes were identified in the National Center for Biotechnology Information database and analyzed with the Multi-Align program (http://dot.imgen.bcm.tmc.edu). The asterisks below the sequences indicate identical amino acids. Double dots below the sequences indicate conserved amino acids. The joined arrow pairs indicate amino acids replaced by double alanine residues.