FIG. 7.

Comparison of viral and cellular DHFR homologs. (A) Amino acid sequence alignment of the vDHFR of KSHV, RFHVMn, RFHVMm, RRV, and HVS and comparison with the human (NP_000782) and mouse (NP_034179) cellular DHFR. Residues conserved between KSHV, RFHVMn, and RFHVMm are highlighted. An asterisk indicates the presence of an insertion or deletion difference with RRV. (B) Phylogenetic analysis of the alignment in A with the protein maximum-likelihood method. Bootstrap values from 100 replica samplings and the scale for substitutions per site are provided.