FIG. 2.

In silico analysis of the DevA/GntR subfamily. Transcription factor abbreviations are as indicated in Table 2. A. Cladogram built from multiple alignment of the helix-turn-helix motifs (alpha-helices two and three) and structure-based alignment of the DNA-binding domain of the selected GntR members. DevA members appear in a common clade with HutC/GntR members, suggesting, for both subfamilies, a common ancestor for their DNA-binding domain. B. Structure-based alignment of the effector-binding domain of DevA subfamily members, highlighting a novel type of secondary-structure topology for the GntR superfamily.