FIG. 1.

Genomic location of the six lipoprotein multigene families. The truncated ORFs in family 1 could be grouped together with other truncated ORFs to form several full-length genes: MPN587 with MPN586, MPN590 with MPN589, MPN585 with MPN584, and MPN581 with MPN580. MPN591 and MPN583 lacked amino- or carboxyl-terminal sequences that were encoded by adjacent sequences that had been classified as noncoding sequences in the gene map. Each of the truncated ORFs in family 2 could be linked with an adjacent truncated ORF, MPN281 with MPN282, MPN146 with MPN147, MPN364 with MPN363, and MPN097 with MPN098. The full-length sequences generated from each of these pairs had a significant amino acid sequence identity (61%, 55%, 61%, and 56%, respectively) with full-length gene products. In family 3 truncated ORFs MPN439, MPN438, and MPN437 could be linked together, as could MPN442, the MPN436-like ORF, and MPN440, and they shared high sequence identity (65% and 70%, respectively) with the full-length ORF MPN436. There was also sequence similarity with MPN436 in the noncoding regions between the truncated ORFs, indicating that these truncated ORFs probably resulted from several mutations in two originally full-length ORFs. The three overlapping truncated ORFs in family 4, MPN459, MPN458, and MPN457, could be linked together to form a sequence with high similarity (82%) to the single full-length ORF. In family 5 the truncated ORFs MPN650 and MPN649 could be linked, as well as MPN467 and MPN466, and these pairs had high levels of identity with full-length genes (48% and 75%, respectively). Family 6 consisted of nine full-length ORFs. No truncated ORFs were found.