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Further substitution analysis of residues in the H3 loop of b12. Bars indicate the apparent affinities of Fab mutants relative to wild-type (w.t.) Fab b12 for gp120JRFL, gp120IIIB, and the B2.1 peptide. Substitutions were made to Trp100 (A), Asp residues near the crown of the H3 loop (B), selected H3 residues N-terminal to Trp100 (C), and key residues C-terminal to Trp100 (D).
