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Effect of substitutions in the CDR loops L1 and L3 of b12 on the relative binding of Fab b12 to gp120JR-FL, gp120IIIB, and the B2.1 peptide. Bars indicate the apparent affinities of Fab mutants relative to wild-type (w.t.) Fab b12 for gp120JR-FL, gp120IIIB, and the B2.1 peptide. The mutations R29S, R31S, and R32Y were back mutations to the residues encoded by the closest related germ line DNA (see Fig. 1).
