TABLE 3.
Repeat no. | Residue position | Repeat sequence | ||||||
---|---|---|---|---|---|---|---|---|
1 | 100 | E | G | K | F | F | N | I |
2 | 107 | D | K | K | F | E | Q | V |
3 | 114 | D | L | R | F | Q | Q | I |
4 | 121 | D | Q | R | F | Q | Q | V |
5 | 128 | D | Q | R | F | Q | Q | V |
6 | 135 | D | Q | R | F | Q | Q | V |
7 | 142 | E | D | K | I | H | K | L |
8 | 149 | D | I | R | I | G | K | V |
9 | 156 | E | S | R | L | D | V | V |
10 | 163 | E | E | K | I | D | V | L |
11 | 170 | N | N | K | F | D | K | L |
12 | 177 | D | N | K | F | D | K | M |
Consensus sequenceb | D | Q | R | F | Q | Q | V | |
E | N | K | I | D | K | L |
This region, exhibiting 12 repeat units in Apl2, is about the same length as a typical AT-2 domain. Corresponding repeat units can be detected in the N-terminal regions of many AT-2 domains as revealed in Fig. 1 (horizontal lines at top left of the figure; see legend). The numbers of the 12 C-terminal 7-residue repeats in Apl2 are presented in column 1, while the residue position at the beginning of each repeat is indicated in column 2.
The two dominant residues at each position are presented in the consensus sequences.