TABLE 1.
Patient characteristics
Patienta | Genderb | Age (yr) | Ethnicityc | HLA-A2 | % of blood CD8+ T cells specific for HLA-A*0201-restricted peptidesd in:
|
CD4+ T cellse | Viral load (Copies/ml)e | Antiretroviral therapy | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV Gag
|
HIV Pol
|
CMV pp65
|
|||||||||||
PBMC | GALT | PBMC | GALT | PBMC | GALT | ||||||||
C01 | M | 23 | H | + | 0.00 | 0.00 | ND | ND | 0.33 | 0.20 | ND | ||
C02 | F | 40 | C | + | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | ND | ||
G01 | M | 54 | C | − | 0.02 | ND | 0.02 | ND | 0.01 | ND | 871 | <50 | Yes |
G02 | M | 33 | C | + | 0.28 | 0.55 | 0.02 | ND | 1.06 | 0.09 | 394 | 72,000 | No |
G03 | M | 41 | C | + | 0.02 | 0.02 | 0.01 | 0.02 | 0.68 | 0.30 | 136 | 169,000 | Yes |
G04 | F | 46 | C | + | 0.69 | 1.20 | 0.85 | 1.00 | 2.02 | 0.18 | 170 | 260,000 | No |
G05 | M | 35 | C | + | 0.00 | 0.07 | 0.00 | ND | 3.53 | 0.27 | 417 | 13,017 | No |
G10 | M | 45 | C | + | 0.00 | 0.00 | 0.02 | ND | 1.22 | 0.07 | 235 | 8,000 | No |
G11 | F | 44 | A | + | 0.68 | 2.60 | 0.02 | ND | 0.15 | 0.02 | 324 | 5,130 | No |
G12 | M | 52 | C | + | 0.17 | 0.28 | ND | ND | 0.42 | 0.18 | 350 | 12,858 | No |
G13 | M | 37 | A | + | 1.53 | 0.57 | 0.02 | ND | 2.81 | 0.41 | 329 | 148,000 | Yes (6 days) |
G22 | M | 29 | C | + | 1.28 | 1.22 | 0.76 | ND | 0.05 | 0.03 | ND | ND | No |
G25 | M | 39 | A, H | + | 0.18 | 0.60 | 0.00 | ND | 0.13 | 0.04 | 671 | 45,378 | Yes |
C01 and C02 are HLA-A*0201-positive, HIV-negative controls. C01 is CMV seropositive, and C02 is CMV seronegative.
M, male; F, female.
C, Caucasian; A, African American; H, Hispanic or Latino.
As determined by tetramer staining. Samples with a distinct tetramer binding population consisting of >0.03% CD8+ T cells were considered positive (see text).
CD4+ T-cell count and viral load were obtained from most recent clinic records.
ND, not determined.