Skip to main content
. 2000 Jan 18;97(2):751–755. doi: 10.1073/pnas.97.2.751

Figure 3.

Figure 3

Differential susceptibility of IGTP-deficient mice to pathogens. (A) Wild-type, IGTP-deficient (IGTP KO), or IFN-γ receptor-deficient (IFNgR KO) mice were inoculated i.p. with the indicated doses of L. monocytogenes, and mortality was assessed over a 14-day period. (B) Wild-type, IGTP-deficient, or IFN-γ receptor-deficient mice were inoculated i.p. with 1,000 L. monocytogenes; after 3 days, the number of bacteria in the liver was determined. (C) Wild-type or IGTP-deficient mice were inoculated with 105 plaque-forming units MCMV i.p.; after 36 or 72 h, the number of virus in the liver was determined. (D) Wild-type and IGTP-deficient mice were inoculated i.p. with 20 cysts ME49 strain T. gondii. The cumulative mortality of the indicated numbers of IGTP-deficient mice (◊) or wild-type mice (□) was followed for 40 days after infection. The graph is representative of three experiments.