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. 2003 May;77(10):5837–5845. doi: 10.1128/JVI.77.10.5837-5845.2003

FIG. 4.

FIG. 4.

Molecular modeling of N255D and N265D mutations. (A) A close-up view showing the D255 side chain having lost its contact with the DNA primer backbone due to loss of hydrogen bonding and electrostatic repulsion. (B) View showing D265 residue that loses the hydrogen bond to O4′ and O2′ of one ribose while gaining a hydrogen bond to O2′ of a neighboring template ribose. (C) View showing the D265 residue, which loses both H bonds and is repelled from the template DNA strand. The results of the N255D simulation with a DNA template were essentially the same as for the RNA template and are not shown.