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The cyclic peptide inhibits AcChoR degradation induced by mAb 198. TE671 cells were treated with 1 μg/ml of mAb 198 alone or after preincubation with indicated concentrations of cyc.ext.Pep.1. After a 3-h incubation at 37°C, cell surface AcChoR content was quantified by 125I-α-bungarotoxin binding.
