TABLE 3.
Comparison of declines in CMV-specific immune responses at the time of death in SIV-infected rhesus macaques with and without CMV disease
| CMV end-organ disease at death (n) | CMV binding Abs
|
CMV-neutralizing Abs
|
CMV-specific CD4+ T lymphocytes
|
CMV-specific CD8+ T lymphocytes
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. with decline | Fold decline | No. with decline | Fold decline | No. with decline | No. undetectable | Fold decline | No. with decline | No. undetectable | Fold decline | |
| Present (6) | 5/6 | 2-16 | 5/6 | 3-4 | 6/6 | 6/6 | 67-2,788 | 6/6 | 2/6 | 4-913 |
| Absent (5) | 1/5 | 2 | 1/5 | 5 | 4/5 | 2/5 | 2-865 | 3/5 | 0/5 | 3-4 |
| P valuea | 0.080 | 0.080 | 0.455 | 0.182 | ||||||
a
Fisher's exact probability test.