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. 2006 Aug 15;4(9):e271. doi: 10.1371/journal.pbio.0040271

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© 2006 Tsuriel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Composite image of a neuron expressing CFP and PA-GFP:ProSAP2. Only CFP fluorescence is shown here.

(B) PA-GFP:ProSAP2 fluorescence for same region as in (A). At time t = 0, PA-GFP:ProSAP2 within the cell body was photoactivated by selective illumination of the soma at 405 nm. With time, photoactivated PA-GFP:ProSAP2 migrated to PSDs along the dendrites, initially to proximal PSDs and later to more distal ones. During the time-lapse session, recurrent, low-level photoactivation of the soma was performed, to maintain a constant level of somatic, photoactivated PA-GFP:ProSAP2.

(C) Quantification of fluorescence changes at the soma.

(D) Quantification of fluorescence changes at PSDs, grouped according to distance from the soma. Fluorescence data for each PSD were normalized to prephotoactivation fluorescence levels for the same PSD. Bar, 20 μm.