Table 1.
Pairwise analysis of off-target effects of dsRNA
| −5.9 | Moderately similar to RAS-RELATED PROTEIN RAB-7 |
| −5.4 | Delta-catenin mRNA, complete cds. |
| −4.9 | Plexin C1 (PLXNC1) |
| −4.7 | Phospholipase A2, group VII |
| −4.6 | Myeloid cell nuclear differentiation antigen |
| −4.6 | Dsarcosine dehydrogenase (SARDH) |
| −4.6 | UDP glycosyltransferase 2 family, polypeptide A1 |
| −3.9 | Fasciculation and elongation protein zeta 1 (zygin I) |
| −3.9 | ATP-binding cassette, sub-family C (CFTRMRP) |
| −3.8 | Ninein (LOC51199) |
| −3.8 | MIP-1 delta mRNA |
| −3.6 | Protein phosphatase 1, regulatory (inhibitor) |
| −3.6 | Growth factor independent 1B |
| −3.5 | Wilms tumor suppressor protein human |
| −3 | Transcription factor 15 (basic helix-loop-helix) (TCF15) |
| −3 | Protein kinase C, zeta (PRKCZ) |
| −2.9 | G protein-coupled receptor kinase 5 |
| −2.7 | Protein kinase, cAMP-dependent, regulatory, type I, beta |
| −2.7 | Ribosomal protein S6 kinase, 90kD, polypeptide 6 (RPS6KA6) |
| −2.6 | TNF superfamily, member 8 (TNFRSF8) |
| −2.5 | Zinc finger protein (ZNF154) |
| −1.9 | Platelet-activating factor receptor |
| −1.9 | Receptor-associated coactivator 3 (RAC3) |
| −1.8 | Hepatocellular carcinoma-associated gene TD26 (LOC55908) |
| −1.3 | Protein kinase, AMP-activated, beta 1 (PRKAB1) |
| −1.3 | Small nuclear RNA activating complex (SNAPC2) |
| −1.3 | Guanine nucleotide binding protein (G protein) (GNB3) |
| −1 | Calciumcalmodulin-dependent protein kinase II beta 6 (CAMKB) |
| −0.9 | Protein kinase, cAMP-dependent, regulatory, type II, _ |
| −0.9 | Interleukin-1 Superfamily z (FIL1(ZETA)) |
| −0.8 | N6-DNA-methyltransferase (N6AMT1) |
| −0.8 | GTPase activating protein-like (GAPL) |
| −0.8 | Cell-line MDA-MB-453 androgen receptor |
Interferon β, 2′-5′ OAS and PKR were found absent, present and present with no change in the expression level when compared with vector alone transfected cells, respectively. Selected changes and the log change following dsRNA treatment are listed below. The complete list of changes in expression pattern can be found in Supplemental Table 2.