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. 1977 May;28(2):302–305.

Depletion of circulating T lymphocytes in pregnancy.

R Bulmer, K W Hancock
PMCID: PMC1540769  PMID: 301450

Abstract

Changes were assessed in lymphocyte sub-populations in various stages of human pregnancy. The percentage and absolute number of E-RFC decreased during pregnancy. There was a concomitant rise in the percentages of EAC-RFC and cells bearing SmIg with little change in their absolute numbers. EAC-RFC continued to rise post-natally.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bianco C., Patrick R., Nussenzweig V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970 Oct 1;132(4):702–720. doi: 10.1084/jem.132.4.702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brain P., Marston R. H., Gordon J. Immunological responses in pregnancy. Br Med J. 1972 Nov 25;4(5838):488–488. doi: 10.1136/bmj.4.5838.488-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Campion P. D., Currey H. L. Cell-mediated immunity in pregnancy. Lancet. 1972 Oct 14;2(7781):830–830. doi: 10.1016/s0140-6736(72)92201-5. [DOI] [PubMed] [Google Scholar]
  4. Gatti R. A. Serum inhibitors of lymphocyte responses. Lancet. 1971 Jun 26;1(7713):1351–1352. doi: 10.1016/s0140-6736(71)91906-4. [DOI] [PubMed] [Google Scholar]
  5. Gergely P., Dzvonyàr J., Szegedi G., Fekete B., Szabò G., Petrànyi G. T and B lymphocytes in pregnancy. Klin Wochenschr. 1974 Jun 15;52(12):601–602. doi: 10.1007/BF01468504. [DOI] [PubMed] [Google Scholar]
  6. Gisler R. H., Fridman W. H. Suppression of in vitro antibody synthesis by immunoglobulin-binding factor. J Exp Med. 1975 Aug 1;142(2):507–517. doi: 10.1084/jem.142.2.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. ITO T., HOSHINO T. Studies of the influences of pregnancy and lactation on the thymus in the mouse. Z Zellforsch Mikrosk Anat. 1962;57:667–678. doi: 10.1007/BF00410229. [DOI] [PubMed] [Google Scholar]
  8. Leikin S. Depressed maternal lymphocyte response to phytohaemagglutinin in pregnancy. Lancet. 1972 Jul 1;2(7766):43–43. doi: 10.1016/s0140-6736(72)91300-1. [DOI] [PubMed] [Google Scholar]
  9. Millar K. G., Mills P., Baines M. G. A study of the influence of pregnancy on the thymus gland of the mouse. Am J Obstet Gynecol. 1973 Dec 1;117(7):913–918. doi: 10.1016/0002-9378(73)90061-6. [DOI] [PubMed] [Google Scholar]
  10. Nakakita T., Ito Y., Noguchi M., Yamada M. Subpopulation of lymphocytes in pregnant women and reactivity of T cells to human trophoblast cells. Acta Obstet Gynaecol Jpn. 1973 Jul;20(3):159–164. [PubMed] [Google Scholar]
  11. Nelson J. H., Jr, Hall J. E., Manuel-Limson G., Freidberg H., O'Brien F. J. Effect of pregnancy on the thymolymphatic system. I. Changes in the intact rat after exogenous HCG, estrogen, and progesterone administration. Am J Obstet Gynecol. 1967 Aug 1;98(7):895–899. [PubMed] [Google Scholar]
  12. Papamichail M., Brown J. C., Holborow E. J. Immunoglobulins on the surface of human lymphocytes. Lancet. 1971 Oct 16;2(7729):850–852. doi: 10.1016/s0140-6736(71)90224-8. [DOI] [PubMed] [Google Scholar]
  13. Papamichail M., Holborow E. J., Keith H. I., Currey H. L. Subpopulations of human peripheral blood lymphocytes distinguished by combined rosette formation and membrane immunofluorescence. Lancet. 1972 Jul 8;2(7767):64–66. doi: 10.1016/s0140-6736(72)91553-x. [DOI] [PubMed] [Google Scholar]
  14. Purtilo D. T., Hallgren H. M., Yunis E. J. Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy. Lancet. 1972 Apr 8;1(7754):769–771. doi: 10.1016/s0140-6736(72)90522-3. [DOI] [PubMed] [Google Scholar]
  15. Silveira N. P., Mendes N. F., Tolnai M. E. Tissue localization of two populations of human lymphocytes distinguished by membrane receptors. J Immunol. 1972 May;108(5):1456–1460. [PubMed] [Google Scholar]
  16. Smith J. K., Caspary E. A., Field E. J. Lymphocyte reactivity to antigen in pregnancy. Am J Obstet Gynecol. 1972 Jul 1;113(5):602–606. doi: 10.1016/0002-9378(72)90628-x. [DOI] [PubMed] [Google Scholar]
  17. Strelkauskas A. J., Wilson B. S., Dray D., Dodson M. Inversion of levels of human T and B cells in early pregnancy. Nature. 1975 Nov 27;258(5533):331–332. doi: 10.1038/258331a0. [DOI] [PubMed] [Google Scholar]

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