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. 1977 Apr;28(1):19–26.

Human antibody-dependent cell-mediated cytotoxicity against target cells infected with respiratory syncytial virus.

R Scott, M O de Landazuri, P S Gardner, J J Owen
PMCID: PMC1540874  PMID: 862248

Abstract

A chromium release assay was established to study human antibody-dependent cell-mediated cytotoxicity (ADCC) of HEp 2 cells infected with respiratory syncytial (RS) virus. Human peripheral blood lymphocytes in the presence of specific antibody to RS virus caused in vitro lysis of RS virus infected target cells. ADCC was detected in sera of infants with RS virus infections and in specimens of colostrum. The ability of serum or colostrum to mediate the cytotoxic reaction appeared to be related to the level of specific IgG, or IgA antibody to RS virus, as detected by membrane fluorescence. Separation of effector cells by their glass adherence properties showed that the ability to produce cytotoxicity resided in non-adherent effector cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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