Table 1.

CM(A), no apparent brain pathology

Patient no.	Age (mo)	Sex	Parasitaemia (Pf) &/or Organism cultured	Admitting coma score	Coma duration Before/After admission (h)	Brain vessel iNOS (n)	Brain vessel MIF (n)	Parasites in brain vessels	Chest Wall vessel iNOS	Chest Wall vessel MIF	Chest Wall muscle iNOS
4	20	M	18.6%	2	missing/6	0-1+ (6)	0 (3)	1+	0-1+	4+	2+
7	29	F	4+	0	1/1	0-1+ (6)	0 (3)	1+	0-1+	3+	4+
31	39	M	49%	1	7/22	0-1+ (9)	0 (3)	1+	0-1+	3+	0-1+
33	25	M	0.26%	0	2/15	0-1+ (8)	0 (3)	1+	2+	2+	0-1+
37	6	M	34% ¶ mal. trace	2	missing/14	0-1+ (9)	0 (3)	1+	3+	3+	3+
47	22	F	11%	1	6/44	0-1+ (13)	0 (3)	1+	0-1+	3+	0-1+
49	17	M	0.09%	1	2/34	0-1+ (12)	0 (3)	1+	2+	3+	4+
22	18	M	1.75%	0	1/3	2+ (8)	0 (3)	1+	3+	ND	2+
38	84	F	22%	0	5/35	2+ (9)	0 (3)	1+	0-1+	2+	0-1+
45	34	M	2.5%	0	8/28	2+ (13)	0 (3)	1+	0-1+	3+	0-1+
23	30	F	29%	0	5/7	3+ (9)	0 (3)	1+	3+	3+	0-1+
CM(B), sequestered parasites only
5	14	M	3.5%	1	NA/18	0-1+ (3)	0 (3)	4+	4+	3+	4+
21	25	F	0.33%	2	2/12	0-1+ (3)	0 (3)	4+	4+	4+	4+
16	51	F	5.5%	1	22/6	0-1+ (3)	0 (3)	2+	2+	4+	2+
39	18	M	0.27%	2	6/18	0-1+ (9)	0 (3)	4+	2+	3+	2+
42	37	F	20%	0	missing	0-1+ (11)	0 (3)	4+	3+	4+	2+
25	44	F	0.02%	2	1/11	2+ (8)	0 (3)	4+	3+	3+	0-1+
1	27	F	31.1%	0	7/18	3+ (3)	0 (3)	2+	2+	ND	2+
CM(C), sequestered parasites plus local intravascular inflammation
13	22	M	36.52%	0-1	15/1	0-1+ (3)	0 (3)	3+	2+	2+	2+
27	20	M	53.4% & Sal. typhi-m	0	missing/3	2+ (3)	0 (3)	3+	4+	3+	0-1+
28	61	F	23.6%	0	12/0	2+ (9)	0 (3)	2+	0-1+	2+	0-1+
29	43	M	33%	2	18/11	3+ (9)	0 (3)	3+	0-1+	3+	0-1+
32	18	F	47%	0	24/3	3+ (9)	0 (3)	3+	0-1+	4+	0-1+
34	70	M	2.4%	1	36/3	3+ (9)	0 (3)	4+	3+	3+	2+
35	114	M	0.21%	1	12/15	3+ (9)	0 (3)	3+	2+	2+	2+
36	21	F	0.88%	2	3/10	3+ (8)	0 (3)	2+	3+	3+	3+
48	48	M	0.03%	2	4/22	3+ (13)	0 (3)	3+	2+	2+	3+
6	17	F	5.8%	0	19/1	4+ (9)	0 (3)	3+	4+	3+	4+
9	16	M	0.03%	1	11/23	4+ (3)	0 (3)	3+	3+	3+	4+
11	29	F	29.5% & H. influ. B	1	28/30	4+ (3)	0 (3)	2+	4+	4+	4+
15	8	F	0.94%	2	8/15	4+ (3)	0 (3)	2+	3+	2+	3+
26	30	M	19%	1	1/31	4+ (9)	0 (3)	4+	4+	4+	missing
COMA (clinically judged not cerebral malaria)
* 8	41	F	negative	3	3/9	3+ (3)	0 (3)	negative	0-1+	4+	0-1+
10	66	F	0.01%	0	5/4	0-1+ (3)	0 (3)	negative	2+	0-1+	2+
12	6	M	Sal. enteritidis	2	1/4	0-1+ (3)	0 (3)	negative	2+	4+	2+
14	9	F	E. coli	0	missing	0-1+ (3)	0 (3)	negative	4+	4+	4+
17	51	F	negative	0	2/9	0-1+ (3)	0 (3)	negative	0-1+	0-1+	0-1+
18	7	F	H. influenzae B	1	48/14	0-1+ (3)	0 (3)	negative	3+	3+	4+
20	96	F	Tuberculosis	0	missing	0-1+ (3)	0 (3)	negative	4+	2+	0-1+
24	48	F	Strep. pneumoniae	3	missing	0-1+ (3)	0 (3)	negative	2+	4+	2+
40	26	F	0.02%	1	24/63	2+ (9)	0 (3)	negative	0-1+	4+	2+
44	21	F	negligible	1	7/3	0-1+ (13)	0 (3)	negative	2+	2+	2+
MALAWIAN CONTROLS (without terminal coma)
41	29	F	Sal. typhimurium	5	NA/NA	0-1+ (13)	0 (3)	negative	0-1+	0-1+	0-1+
* 50	144	F	Strep. pneumoniae	5	NA/NA	0-1+ (13)	0 (3)	negative	0-1+	3+	0-1+
AUSTRALIAN CONTROLS
n = 5		F/M	NA	NA	NA/NA	NA	NA	negative	0-1+	0-1+	0-1+
n = 7		F/M	NA	5	NA/NA	0-1+ (3)	0 (3 ea)	negative	NA	NA	NA

* Serologically positive for HIV (n) Number of brains areas examined ND = not done NA = not applicable