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. 2000 Jan 18;97(2):805–810. doi: 10.1073/pnas.97.2.805

Figure 2.

Figure 2

Cotransfection of ST6-encoding plasmid (pIB6) inhibits CCR5-dependent cell fusion between target cells transiently transfected to express CCR5 and CD4 and effector cells expressing env derived from various HIV-1 or SIV strains. For determination of background luciferase activity, a set of target cells was cotransfected with plasmids encoding CD4 and luciferase but no CCR5-encoding plasmid (“no CCR5”). “Control” indicates fusion assays using target cells cotransfected with plasmids encoding CCR5, CD4, luciferase, and control plasmid pcDNA3.1/Zeo containing no insert. “pIB6” indicates luciferase activity where target cells were cotransfected with plasmids encoding CCR5, CD4, luciferase, and ST6. “pRAN” indicates luciferase activity, where target cells were cotransfected with plasmids encoding CCR5, CD4, luciferase, and RANTES. Relative light units (RLU) are shown on the y-axis. Each bar represents luciferase activity from one well of target cells.