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. 1978 May;32(2):346–351.

Age-dependent changes of human blood lymphocyte subpopulations.

J Clot, E Charmasson, J Brochier
PMCID: PMC1541268  PMID: 307469

Abstract

T- and B-lymphocyte populations were enumerated at four stages of life: at the newly born, infant, adult and aged stages. The proportion of T cells detected by E rosettes and an anti-human T-lymphocyte antigen (HTLA) serum incresed from new-born children to adults, then decreased with ageing. The antiserum detected less mature T cells in aged people. The percentages of cell forming 'active' E rosettes increased with ageing. Lower numbers of B cells bearing surface immunoglobulins were found in adults.Complement receptor-bearing lymphocytes (percentages and absolute numbers) decreased from new-born children to aged humans. Finally, the number of monocytes were significantly greater in the young than in adult and aged people. Such results bring new data concerning the age-dependent changes of lymphocyte subpopulations and concerning the significance of various techniques used together to detect mononuclear cell populations in the human peripheral blood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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