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Serum IgG titers in groups (n = 10) of BALB/c mice immunized with PLG/CTAB microparticles of three different mean sizes (300 nm, 1 μm, and 30 μm) with 1 μg of adsorbed p55 gag DNA. Antibody titers are geometric mean titers ± SE at 2 weeks post-second immunization (week 6) time point. The responses from PLG/CTAB (300 nm and 1 μm) were significantly higher (P < 0.05) than 30 μm and naked DNA group.
