Table 1.

Cationic microparticles with adsorbed DNA: Particle size, net surface charge, loading efficiency, and DNA loading levels based on hydrolysis of PLG-DNA formulation

Formulation	Mean size, μm	Zeta potential, mV	Loading level, % wt/wt	Mean loading efficiency, %
PLG/CTAB-p55 DNA	1.54  ± 0.20	+36  ± 6	0.92  ± 0.12	92.0
PLG/DDA-p55 DNA	2.20  ± 0.12	+30  ± 10	0.68  ± 0.08	68.0
PLG/DOTAP-p55 DNA	0.98  ± 0.11	+24  ± 8	0.62  ± 0.14	62.0

PLG miroparticles prepared with polyvinyl alcohol as a particle stabilizer, but without cationic surfactants have a zeta potential of −13 ± 3 mV. Values are mean ± SE of triplicate measurements.