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Dynamics of serum Cr (S-Cr) and BUN in rats subjected to 45 min of renal ischemia. Closed circle, closed square, and open triangle denote sham group, iARF group, and iARF with ONO-4057 posttreated group, respectively. Number of animals in each group was six. B indicates “before the initiation of ischemia reperfusion injury.” Asterisk denotes P < 0.01 vs. iARF group.
