Figure 6.

Histological scoring of intensity of ischemia reperfusion injury in kidneys treated with BLT antagonist. Scoring was performed on seven kidneys for sham, eight kidneys for control ischemia (iARF) and ONO-4057 pretreatment + iARF (Pre-Tx), and six kidneys for iARF + ONO-4057 posttreatment (Post-Tx). Asterisk denotes P <0.01 vs. control ischemia. Tub. nec., tubular necrosis; Vasc. infilt., vascular infiltration; Int. inf., interstitial inflammation. L-BB indicates loss of brush borders, and “Cast” indicates cast formation. Mean score was calculated for 13 categories of scoring, as previously described (16).