Table 1.

BUN and serum Cr levels in rats subjected to 45 min of iARF: Efficacy of pretreatment with BLT antagonist ONO-4057

	BUN, mg/dl	Serum Cr, mg/dl
Control (n = 7)	12.7  ±  1.2	0.33  ±  0.04
Sham operation (n = 7)	13.2  ±  0.3	0.33  ±  0.02
Ischemia reperfusion (n = 8)	110.5  ±  10.0*	2.55  ±  0.32*
ONO-4057 pretreatment + ischemia reperfusion† (n = 8)	31.3  ±  1.4‡	0.73  ±  0.051‡
Ischemia reperfusion + ONO-4057§ (n = 6)	65.0  ±  6.8¶	1.15  ±  0.12¶

BUN and serum Cr were obtained on postoperative day 1. *P < 0.001 (sham operation vs. ischemia reperfusion). 

^† ONO-4057 (7 g/kg rat chow) was fed for 4 wk. 

^‡ P < 0.001 (ischemia reperfusion vs. ONO-4057 pretreatment + ischemia reperfusion). 

^§ ONO-4057 300 mg/kg was subcutaneously injected 15 min after the initiation of renal reperfusion. 

^¶ P < 0.001 (ischemia reperfusion vs. ischemia reperfusion + ONO 4057) and P < 0.005 (ONO-4057 pretreatment + ischemia reperfusion vs. ischemia reperfusion + ONO-4057).