Figure 4.

The tolerance of DFP-pretreated nude mice to chronic treatment with cytotoxic SST analog AN-238 as assessed by the loss in BW. AN-238 was administered at 300 nmol/kg (○) on days 0, 14, and 28 (arrows pointing down) or at 400 nmol/kg (●) on days 0, 17, and 34 (arrows pointing up). Mice that received 3 × 400 nmol/kg showed progressive loss in BW after the last injection and died within 4 weeks.