Table 2.
EFfect of pretreatment with paraoxon on the tolerance of nude mice to AN-238
| Dose of AN-238,* nmol/kg, i.v. | Paraoxon, mg/kg, s.c.
|
|||||
|---|---|---|---|---|---|---|
| 0.4 | 0.8 | 1.0 | 1.0 + 0.5† | 1.5 | 2.0 | |
| Survival rate after injection of paraoxon‡ | ||||||
| 2/2 | 5/5 | 4/4 | 11/11 | 1/5 | 1/3 | |
| Survival rate after injection of AN-238‡ | ||||||
| 225 | — | — | — | 4/5 | — | — |
| 300 | — | — | — | 4/5 | — | — |
| 350 | — | 0/3 | 0/2 | — | 0/1 | 0/1 |
| 400 | 0/2 | 0/2 | 0/2 | 0/1 | — | — |
*
Various doses of AN-238 were administered 30 min after pretreatment with paraoxon.
†
These animals received paraoxon in two consecutive injections: 1.0 and 5.0 mg, 15 min part.
‡
Number of animals surviving/number of animals treated.