Figure 5.

Time course of IgG anti-goat responses in mice immunized with mAb N418 and a noninteracting goat antigen. (A) IgG responses of individual CBA mice. Group 1 received 0.5 μg of goat anti-biotin antibody and Group 2 received 0.5 μg each of goat anti-biotin antibody and mAb N418 on day 0. Blood was drawn periodically after immunization, starting from day 7. (B) Time course plot of BALB/c mice, data presented as described for A. Note the lack of response in the mice that received the mixture of goat anti-biotin antibody and mAb N418.