Table 4.
The 1q42 and 1q21 breaks do not require viral gene expression, but do require viral binding and/or penetration
| Sample | No. aberrant cells/100 | No. of cells with specific breaks
|
||||
|---|---|---|---|---|---|---|
| 1q42 (×1) | 1q42 (×2) | 1q21 (×1) | 1q21 (×2) | 1q42 + 1q21* | ||
| Exp. 9 | ||||||
| HCMV Towne | 18 | 11 | 0 | 4 | 1 | 2 |
| HCMV Towne + UV | 22 | 11 | 0 | 2 | 1 | 3 |
| Mock | 1 | 0 | 0 | 1 | 0 | 0 |
| Exp. 10† | ||||||
| HCMV Towne | 20 | 10 | 0 | 4 | 0 | 2 |
| HCMV Towne + UV | 14 | 12 | 0 | 2 | 0 | 0 |
| Mock | 0 | 0 | 0 | 0 | 0 | 0 |
| Exp. 11† | ||||||
| HCMV AD169 | 6 | 6 | 0 | 0 | 0 | 0 |
| HCMV + CH253 | 0 | 0 | 0 | 0 | 0 | 0 |
| HCMV + cytogam | 0 | 0 | 0 | 0 | 0 | 0 |
| HCMV + control Ab | 8 | 6 | 0 | 2 | 0 | 0 |
| Mock | 0 | 0 | 0 | 0 | 0 | 0 |
HCMV Towne was UV-irradiated to eliminate viral gene expression and then used to assay for damage in experiments 9 and 10. In addition, HCMV AD169 was incubated with either control or neutralizing Abs before exposure to cells in Experiment 11. See Table 1 for explanation of ∗ and †.