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. 2003 May 1;31(9):2393–2400. doi: 10.1093/nar/gkg343

Figure 2.

Figure 2

Induction of cytokine secretion by CpG DNAs in BALB/c mouse spleen cell cultures. BALB/c mouse spleen cells were cultured and activated with CpG DNAs 1 (squares) and 2 (circles) at various concentrations for 24 h, and the levels of secreted IL-12 (top) and IL-6 (bottom) in the culture medium were measured by ELISA. See Materials and Methods for cell culture and ELISA protocols. M stands for medium-treated control (filled square). Each value is an average of three replicates, and the results are representative of at least two independent experiments.