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Domain structure of mouse Cripto. Conserved domains of Cripto are shown including the N-terminal signal peptide, EGF-like domain (EGF), CFC domain, and C-terminal hydrophobic region containing the site of glycosylphosphatidylinositol (GPI) attachment. The sites of three tandem point mutations are also indicated (mEGF1, N69G and T72A; mEGF2, R88G and E91G; mCFC, H104G and W107G).
