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Acidic pH-induced H2AX phosphorylation is defective in a TOP2 mutant cell line. (A) HL-60 and HL-60/MX2 cells were treated with VM-26 (10 μM), CPT (10 μM), and different pH media for 1 h. Cells were then lysed and processed for detection of the phosphorylated H2AX. (B) HL-60 and HL-60/MX2 cells were lysed and processed for detection of TOP2α and TOP2β.
