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Human AT1R overexpression in cardiomyocytes induced massive remodeling of the heart. Hearts from age-matched Wt and Tg 27 mice were washed with PBS and fixed in neutral formaldehyde. Hearts were cleaned up of connective tissue, were photographed, were sectioned in two, were cleaned up of blood clots, and were rephotographed at the same magnification. *, the fibrotic tissue in the left atrium. (Bar = 1 mm.)
