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Prevention of the hypertrophic phenotype by the AT1R antagonist losartan. Five-micrometer heart sections from 120-day-old Tg mice treated with vehicle (A and B) or losartan (C and D) were stained for collagen with Masson's trichrome (A and C) or were immunostained with the anti-ANF antibody (B and D). Control Wt littermates are similarly presented (E and F). (Bar = 50 μm.)
