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DNA-damage-induced apoptosis in transformed MEFs. (A) Northern blot analysis of mouse HIPK1 transcripts in E1A/Ras-transformed MEFs. (B) Colony formation assay. The mean number ± SD of colonies formed in triplicate experiments by two independent clones each of HIPK1+/+- and HIPK1−/−-transformed MEFs is shown. (C) Apoptosis of transformed MEFs induced by γ-irradiation at the indicated doses. Comparable results for experiments in B and C were obtained in three independent trials.
