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Intra-peritoneal minocycline 45 mg/kg treatment twice a day (first dose immediately after reperfusion), significantly reduced the ischemia-induced increase in MMP-2 and MMP-9 total protein concentrations as compared to PBS treated control animals. Sample sizes: PBS n = 6; Minocycline n = 6 (p < 0.038 for MMP-9 and p < 0.018 for MMP-2). Each band represents one different replicate sample.
