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Comparison of the coupling yields for synthesis of PR(81–99). ♦, HBTU/Boc in situ neutralization chemistry (27), consisting of 10-min coupling times, 22-min cycles, and an average manual synthesis time of ≈7 h. ○, HATU/Boc in situ neutralization chemistry, consisting of 2-min coupling times, 5 min cycles, and a synthesis time of 2.1 h.
