Figure 2.

LTP and LTD induced by pairing protocols cannot be increased further by tetanic stimulation. (A Lower) Summary graph showing that SP induced saturated LTP in both control (○) and CPP-treated (●) slices, and, therefore, no further potentiation was induced with 100-Hz tetanic stimulation. (B Lower) Summary graph illustrating that 1-Hz stimulation failed to enhance LTD induced with AP in both control (○) and CPP-treated (●) slices, indicating that LTD already was saturated with AP. (A and B Upper) Representative traces of EPSPs evoked at marked time points are illustrated. (Insets) Superimposed rising phases of evoked EPSPs at a higher magnification.