Figure 4.
Chronic blockade of NMDA receptors decreases the AMPA/NMDA ratio of evoked EPSCs (eEPSCs) but not of mEPSCs. (A) Representative traces of evoked EPSCAMPA and EPSCNMDA recorded in the same cell at −70 mV and +30 mV, respectively, from control and CPP-treated slices. (B) Superimposed averaged traces of mEPSCs from control and CPP-treated slices recorded in the absence of extracellular magnesium and during application of CPP (100 μM), together with traces of mEPSCNMDA obtained by their subtraction. (C) Cumulative distributions of the AMPA/NMDA ratios of evoked EPSCs (Left), miniature EPSCs (Center), and their normalized values (Right) in control and CPP-treated slices. A significantly lower evoked AMPA/NMDA current ratio was found in CPP-treated slices. * indicates statistical significance (P < 0.05).