Figure 1.

Cardiovascular effects of HNO/NO⁻ in failing myocardium and vasculature. (A) Example of pressure–dimension relationships at baseline (Upper) and after HNO/NO⁻ (AS) (Lower). The basal cardiac cycle is the pressure–dimension loop to the far right of each set, with the subsequent data obtained during preload reduction by transient vena cava occlusion. AS lowered preload (end-diastolic dimension, EDD; arrow), shifting the set of loops leftward, and also increased contractility (denoted by upward-left shift of end-systolic pressure–dimension relation; arrow). (B) Mean data contrasting inotropic, lusitropic, and loading effects of HNO/NO⁻ (AS), DEA/NO, and NTG. D_EDD, dP/dt_max–end-diastolic dimension relation slope; Tau, relaxation time constant; ESP, end-systolic pressure; EDP, end-diastolic pressure; Ea, arterial elastance (afterload).